Universal library

DNA synthesis technology has greatly developed over recent years, serving a growing multi-billion synthetic DNA market. Synthetic DNA is used in projects that optimize reagents, chemicals, crops and other organisms, in projects seeking to increase the manufacturing efficiency for the above, as well as in studies of molecular regulation and other cellular processes. The latter was the focus of the MRG-GRammar H2020 FET project.

As part of the results of MRG-Grammar, we have developed a universal regulatory library that is made of binding site motifs that have been shown to be highly active in every cell type that we have tested from yeast to mammalians. The library is synthesized with a new composite-base technology that was also developed in MRG-Grammar.

In this study, we explore the application space for the universal library and resultant market potential. Requested funding will be used to complete the universal library prototype and to demonstrate that expression of a biologic can be optimized with this tool. In addition, we will explore a potential service model, business model, and a licensing mechanism for the dissemination of the universal library for various stake-holders in the academia and private sectors.

This project was funded by the European Union’s Horizon 2020 Research and Innovation Programme under grant agreement no. 851615.