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Our Goal

The genome harbors multiple codes. The genetic code was just the first one to be discovered. In order to decipher and decode the genome, we need to establish a Biological Rosetta stone. Our research is dedicated to achieving this goal.

Approach

We begin with a model-based design of DNA sequences, followed by synthetic biology experiments, and analysis using advanced bioinformatic, thermodynamic, and stochastic models. The results of the experiments and analysis provide feedback to the design model, which then generates an improved set of sequences. This process is repeated until a robust model for the encoding rules is generated.

Methodology

We design and construct oligo libraries of tens of thousands of synthetic DNA sequences using various numerical approaches.
We use state-of-the-art liquid automated robotics, next generation sequencing  and  time-lapse imaging to carry out our measurements.
We carry out our experiments in vivo in a host of model cell lines: bacteria, yeast, mammalian cell lines.

Open Positions

M.Sc. students
Ph.D. students
Post-doctoral scholars
Please send CV and two recommendations to roeeamit@technion.ac.il
or call: +972-77-887-1895

 

News & Events

1.12.2020 – Congratulations to Noa Navon on completing her M.Sc.!

1.11.2020 – Congratulations to the 2020 iGEM Technion team for winning a gold medal and being nominated for the Best Inclusion award.

19.10.2020 – Congratulations to Noa Katz on completing her Ph.D.!

13.2.2020 – Congratulations to Noa Katz on receiving the prestigious Fulbright postdoctoral fellowship!

1.1.2020 – Congratulations to Naor Granik on successful completion of his M.Sc. degree!