Our Goal
The genome harbors multiple codes. The genetic code was just the first one to be discovered. In order to decipher and decode the genome, we need to establish a Biological Rosetta stone. Our research is dedicated to achieving this goal.
Approach
We begin with a model-based design of DNA sequences, followed by synthetic biology experiments, and analysis using advanced bioinformatic, thermodynamic, and stochastic models. The results of the experiments and analysis provide feedback to the design model, which then generates an improved set of sequences. This process is repeated until a robust model for the encoding rules is generated.
Methodology
We design and construct oligo libraries of tens of thousands of synthetic DNA sequences using various numerical approaches.
We use state-of-the-art liquid automated robotics, next generation sequencing and time-lapse imaging to carry out our measurements.
We carry out our experiments in vivo in a host of model cell lines: bacteria, yeast, mammalian cell lines.
Open Positions
M.Sc. students
Ph.D. students
Post-doctoral scholars
Please send CV and two recommendations to roeeamit@technion.ac.il
or call: +972-77-887-1895
News & Events
16.3.2024 – Congratulations to Inbal on the acceptance of her paper “A universal system for boosting gene expression in eukaryotic cell-lines” to Nature Communications!
11.3.2024 – Congratulations to Sarah on receiving the Technion Administrative Staff Excellence Award for 2023!
2.11.2023 – Grand Jamboree of the 2023 Technion iGEM team!
1.4.2023 – iGEM 2023 Kickoff!
10.11.2022 – Congratulations to Naor on the acceptance of his paper “Formation of synthetic RNA protein granules using engineered phage-coat-protein -RNA complexes” to Nature Communications!
26.10.2022 – Congratulations to the 2022 Technion iGEM team for winning multiple awards!
22.10.2022 – Congratulations to Dr. Inbal Vaknin on her successful PhD defense!
13.6.2022 – Congratulations to the lab for receiving the 2022 Hilda and Hershel Rich Innovation Award!
9.2021 – Congratulations to Naor for receiving the Miriam and Aaron Memorial Gutwirth Graduate Scholarship!