The genome harbors additional codes. The genetic code was just the first one to be discovered. In order to decipher and decode the genome, we need to make a Biological Rosetta stone. Our research is dedicated to achieving this goal.
To decipher encoding rules, we use an iterative approach, which begins with a model-based design of DNA sequences, synthetic biology experiments, analysis using advanced bioinformatic, thermodynamic, and stochastic models. The results of the experiments and analysis feed-back on the design model, which generates an improved set of sequences until a robust model for the encoding rules is generated.
We construct thousands of synthetic DNA sequences designed using numerical simulations.
We use liquid automated robotics and state-of-the-art imaging apparatus to carry out our measurements.
We carry out our experiments in vivo in a host of model cell lines: bacteria, yeast, mammalian cell lines.