The Biological Rosetta Stone

Our Goal

 

Approach

 

Methodology

 

The genome harbors additional codes. The genetic code was just the first one to be discovered. In order to decipher and decode the genome, we need to make a Biological Rosetta stone. Our research is dedicated to achieving this goal.

To decipher encoding rules, we use an iterative approach, which begins with a model-based design of DNA sequences, synthetic biology experiments, analysis using advanced bioinformatic, thermodynamic, and stochastic models. The results of the experiments and analysis feed-back on the design model, which generates an improved set of sequences until a robust model for the encoding rules is generated.

We construct thousands of synthetic DNA sequences designed using numerical simulations.
We use liquid automated robotics and state-of-the-art imaging apparatus to carry out our measurements.
We carry out our experiments in vivo in a host of model cell lines: bacteria, yeast, mammalian cell lines.

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Looking for M.Sc, Ph.D, and post-doctoral scholars for a variety of exciting projects in syntheticbiology, biophysics, biological imaging and biofuels.

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Synthetic Biology laboratory launched.

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To find out about the Technion’s iGEM program.