The Biological Rosetta Stone

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Our Goal

The genome harbors additional codes. The genetic code was just the first one to be discovered. In order to decipher and decode the genome, we need to make a Biological Rosetta stone. Our research is dedicated to achieving this goal.


To decipher encoding rules, we use an iterative approach, which begins with a model-based design of DNA sequences, synthetic biology experiments, analysis using advanced bioinformatic, thermodynamic, and stochastic models. The results of the experiments and analysis feed-back on the design model, which generates an improved set of sequences until a robust model for the encoding rules is generated.


We design and construct oligo libraries of tens of thousands of synthetic DNA sequences using various numerical approaches.
We use state-of-the-art liquid automated robotics, next generation sequencing  and  time-lapse imaging to carry out our measurements.
We carry out our experiments in vivo in a host of model cell lines: bacteria, yeast, mammalian cell lines.


Congratulations to Slava for finishing his Ph.D!
Slava has successfully defended his PhD thesis, entitled: “Studying Looping Based Transcriptional Regulation Using Synthetic Biology and Statistical Mechanics Method

Synthetic biology games with RNA in bacteria
7th annual Winter q-bio meeting